- Case Report
- A case of mucolipidosis II presenting with prenatal skeletal dysplasia and severe secondary hyperparathyroidism at birth
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Ju Sun Heo, Ka Young Choi, Se Hyoung Sohn, Curie Kim, Yoon Joo Kim, Seung Han Shin, Jae Myung Lee, Juyoung Lee, Jin A Sohn, Byung Chan Lim, Jin A Lee, Chang Won Choi, Ee-Kyung Kim, Han-Suk Kim, Beyong Il Kim, Jung-Hwan Choi
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Clin Exp Pediatr. 2012;55(11):438-444. Published online November 23, 2012
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Mucolipidosis II (ML II) or inclusion cell disease (I-cell disease) is a rarely occurring autosomal recessive lysosomal enzyme-targeting disease. This disease is usually found to occur in individuals aged between 6 and 12 months, with a clinical phenotype resembling that of Hurler syndrome and radiological findings resembling those of dysostosis multiplex. However, we encountered a rare case of an infant... |
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- A case of McKusick-Kaufman syndrome
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Se-Hyung Son, Yoon Joo Kim, Eun Sun Kim, Ee-Kyung Kim, Han-Suk Kim, Beyong Il Kim, Jung-Hwan Choi
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Clin Exp Pediatr. 2011;54(5):219-223. Published online May 31, 2011
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McKusick-Kaufman syndrome (MKS) is an autosomal recessive multiple malformation syndrome characterized by hydrometrocolpos (HMC) and postaxial polydactyly (PAP). We report a case of a female child with MKS who was transferred to the neonatal intensive care unit of Seoul National University Children's Hospital on her 15th day of life for further evaluation and management of an abdominal cystic mass. She... |
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- Decreased heart sound in a healthy newborn: Spontaneous multiseptated cystic pneumomediastinum with delayed respiratory distress
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Young June Choe, Eun eun Kim, Ee-Kyung Kim, Han-Suk Kim, Jung-Eun Chun, Woo Sun Kim, In-One Kim, Jung-Hwan Choi
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Clin Exp Pediatr. 2010;53(2):244-247. Published online February 15, 2010
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Spontaneous pneumomediastinum in the absence of predisposing risk factors has been rarely observed in full-term neonates. A 3-day-old neonate, delivered vaginally at term without any perinatal complications or signs of respiratory difficulty, was referred to the Seoul National University Children’s Hospital because of reduced heart sound detected during routine neonatal examination. Chest computed tomography (CT) showed air collection in the... |
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- Original Article
- Short-term clinical outcomes of late preterm infants
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Ji Youn Na, Narimi Park, Eun Sun Kim, Jin-A Lee, Gyu Hong Shim, Jin-A Lee, Chang Won Choi, Ee-Kyung Kim, Han-Suk Kim, Beyong Il Kim, Jung-Hwan Choi
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Clin Exp Pediatr. 2009;52(3):303-309. Published online March 15, 2009
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Purpose : To identify the short-term clinical outcomes of late preterm infants and to test the hypothesis that late preterm infants have more clinical problems during the early postnatal period than term infants.
Methods : One hundred late preterm infants [gestational age (GA) 34+0-36+6 weeks] and the same number of term infants (GA 37+0-41+6 weeks) were randomly selected from 289 late... |
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- Clinical characteristics of severe meconium aspiration syndrome
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Chang Won Choi, Beyong Il Kim, Hyun Ju Lee, Kyoung Eun Joung, Gyu Hong Shim, In Suk Lim, Jin-A Lee, Ee-Kyung Kim, Han-Suk Kim, Jung-Hwan Choi
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Clin Exp Pediatr. 2008;51(7):713-721. Published online July 15, 2008
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Purpose : This study aims to describe the clinical characteristics of severe meconium aspiration syndrome (MAS) which required mechanical ventilation over 48 h and to delineate the progress of respiratory failure and radiographic findings in severe MAS.
Methods : Twelve infants admitted to the Neonatal Intensive Care Unit (NICU) of the Seoul National University Bundang Hospital diagnosed with severe MAS from... |
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- Case Report
- A case of congenital vallecular cyst associated with
gastroesophageal reflux presenting with stridor,
feeding cyanosis, and failure to thrive
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Mi Ae Yang, Min Jae Kang, Jeana Hong, Seung Han Shin, Sang Duk Kim, Ee-Kyung Kim, Han-Suk Kim, Jung-Hwan Choi, Tack Kyun Kwon, In-One Kim
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Clin Exp Pediatr. 2008;51(7):775-779. Published online July 15, 2008
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Vallecular cyst is an uncommon but potentially dangerous condition causing stridor and has been associated with sudden airway obstruction resulting in death due to its anatomical location in neonates. It may also present with various degrees of feeding problems resulting in failure to thrive. When a vallecular cyst is suspected clinically, endoscopic laryngoscopy is necessary to visualize it. Other conditions... |
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- Original Article
- Clinical characteristics of severe respiratory syncytial virus infection
requiring mechanical ventilation in neonatal period and early infancy
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Seung Han Shin, Jae Ri Kim, Jin-A Lee, Chang Won Choi, Ee-Kyung Kim, Eun Hwa Choi, Han-Suk Kim, Beyong Il Kim, Hoan Jong Lee, Jung-Hwan Choi
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Clin Exp Pediatr. 2008;51(4):372-376. Published online April 15, 2008
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Purpose : To identify clinical characteristics of severe respiratory syncytial virus (RSV) in neonatal period and early infancy and provide information in clinical practice.
Methods : Twelve neonates and young infants (<6 months) who were infected by respiratory syncytial virus and required mechanical ventilation between March 2005 and July 2007 were enrolled. Diagnosis of RSV infection was made based on the... |
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- Delayed closure effect in preterm infants with patent ductus arteriosus
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Hyun Ju Lee, Gyu Hong Sim, Kyung Eun Jung, Jin A Lee, Chang Won Choi, Ee Kyung Kim, Han Suk Kim, Beyong Il Kim, Jung-Hwan Choi
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Clin Exp Pediatr. 2008;51(10):1065-1070. Published online October 15, 2008
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Purpose : This study aims to determine whether early closure (within 7 d) of significant patent ductus arteriosus (PDA) with indomethacin or ligation reduces neonatal morbidity when compared with delayed closure (after 7 d).
Methods : Fifty-eight extremely-low-birth-weight infants admitted to the NICU of Seoul National University Hospital from April 2005 to May 2007 with PDA were studied retrospectively.
Results :... |
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- Recent outcome of extremely low birth weight infants - The use of CRIB(clinical risk index for babies) Ⅱ score foranalyzing the survival rate -
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Do-Hyeon Kim, So-Yeon Shim, Jae-Ri Kim, Seung-Han Shin, Eun Sun Kim, Kyoung-Eun Joung, Sang Duk Kim, Jin A Lee, Chang Won Choi, Ee-Kyung Kim, Han-Suk Kim, Beyong Il Kim, Jung-Hwan Choi
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Clin Exp Pediatr. 2006;49(9):952-958. Published online September 15, 2006
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Purpose : The survival rate of infants weighing less than 1,000 g at birth(extremely low birth weight infants, ELBWI) has increased due to recent advances in perinatal and neonatal intensive care. The purpose of this study was to evaluate the survival rates of ELBWI born at Seoul National University Hospital during the last six years.
Methods : A total of... |
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- Diagnostic classification and clinical aspects of floppy infants in the neonatal and pediatric intensive care units
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Eun Sun Kim, Kyung Eun Jung, Sang Duk Kim, Eo Kyung Kim, Jong Hee Chae, Han Suk Kim, June Dong Park, Ki Joong Kim, Beyong Il Kim, Yong Seung Hwang, Jung-Hwan Choi
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Clin Exp Pediatr. 2006;49(11):1158-1166. Published online November 15, 2006
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Purpose : The purpose of this study is to make a diagnostic classification and discuss a diagnostic strategy of floppy infants by investigating clinical, neurological, electrophysiological, and genetic analysis of infants admitted to intensive care units with the complaint of hypotonia.
Methods : A retrospective study was performed from Jan. 1993 to Dec. 2005 in neonatal and pediatric intensive care units... |
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- The Effect of Histologic Chorioamnionitis on the Development of Respiratory Distress Syndrome and Chronic Lung Disease in Preterm Infants
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Heui seung Jo, Beyong Il Kim, Chang Won Choi, Jun Dong Park, Chong Jai Kim, Jung-Hwan Choi
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Clin Exp Pediatr. 2004;47(2):150-156. Published online February 15, 2004
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Purpose: Histologic chorioamnionitis may play a role in the development of respiratory distress syndrome(RDS) and chronic lung disease(CLD) independently or through its association with preterm birth. We investigated the relationship between histologic chorioamnionitis and clinical complications including, RDS and CLD, of preterm infants.
Methods: Clinical data were collected retrospectively from 478 preterm infants(gestational period≤34 weeks) who were admitted to the neonatal... |
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- Case Report
- A Case of Citrullinemia Diagnosed at the Neonatal Period
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Seung Kyu Song, Kyung Chang Oh, Mi Ae Hong, Hee Taeg Kim, Hye Jung Shin, Soon Young Kim, Jin Keun Chang, Heui Seung Jo, Beyong Il Kim, Sei Won Yang, Jung-Hwan Choi
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Clin Exp Pediatr. 2002;45(4):524-528. Published online April 15, 2002
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Citrullinemia is a rare inborn error of metabolism of the urea cycle, and was first reported by McMurray, et al. in 1962. It is inherited as an autosomal recessive trait. The normal synthesis of argininosuccinic acid is blocked in this disease due to a deficiency of argininosuccinic acid synthetase(AS), which has been demonstrated in liver cells and fibroblasts. The clinical... |
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- A Case of Subcutaneous Fat Necrosis in Neonate
with Meconium Aspiration Syndrome
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Mi Ae Hong, Kyung Chang Oh, Seung In Ahn, Hye Jung Shin, Jin Keun Chang, Byung Doo Lee, Beyong Il Kim, Jung-Hwan Choi
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Clin Exp Pediatr. 2002;45(11):1422-1425. Published online November 15, 2002
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Subcutaneous fat necrosis in neonates is a rare disease characterized by skin lesions, which may be single or multiple, poorly circumscribed and often tender erythematous nodules or plaques on cheeks, buttocks, back, arms, and thighs. These symptoms are usually self-limited; resolution occurs over a period of weeks to months. Subcutaneous fat necrosis affects full term and healthy- appearing infants who... |
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- A Case of Congenital Methemoglobinemia Due to NADH-Methemoglobin Reductase Deficiency
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Do Hyeon Kim, Jin A Lee, Sung Jae Lee, Heui Seung Jo, Yun Kyoung Lee, June Dong Park, Beyong Il Kim, Jung-Hwan Choi, Dong Soon Lee, Han Ik Cho, Kyung Ran Park
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Clin Exp Pediatr. 2001;44(6):699-704. Published online June 15, 2001
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Congenital methemoglobinemia is caused by NADH-methemoglobin reductase deficiency in more than half of the total reported cases. NADH-methemoglobin reductase deficiency is an uncommon hereditary disorder producing methemoglobinemia and cyanosis in the homozygous subject. A majority of the patients born with these abnormalities have only a cosmetic defect-asymptomatic cyanosis. Congenital methemoglobinemia due to NADH-methemoglobin reductase deficiency is an autosomal recessive disorder... |
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- Original Article
- Classification and Risk Factors for Chronic Lung Disease(CLD)
of Prematurity : Classical CLD Versus Atypical CLD
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Chang Won Choi, Beyong Il Kim, Heui Seung Jo, Jun Dong Park, Chong Jae Kim, Bo Hyun Yoon, Jung-Hwan Choi
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Clin Exp Pediatr. 2001;44(11):1222-1232. Published online November 15, 2001
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Purpose : We tried to classify the different type of CLD and assess the risk factors for classical CLD and atypical CLD.
Methods : Retrospective cohort analysis was done in 120 preterm infants with birth weights less than 1,500 g who were admitted to NICU in Seoul National University Children's Hospital between Jan. 1993 and Dec. 1998 and survived more... |
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- Effects of Cisapride on QTc Interval and QT Dispersion in Preterm Infants
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Heui Seung Jo, Chang Won Choi, Yun Kyung Lee, Hee Seok Kim, Jun Dong Park, Jun Huh, Beyong Il Kim, Chung Il Noh, Jung-Hwan Choi
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Clin Exp Pediatr. 2000;43(2):188-194. Published online February 15, 2000
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Purpose : Cisapride, a prokinetic agent, is widely used in preterm infants with feeding intolerance or gastroesophageal reflux. Although cisapride is regarded as a safe drug, increased QTc interval or ventricular arrhythmia has been reported in adults and neonates. So we prospectively examined the effects of cisapride on the QTc interval and QT dispersion in preterm infants.
Methods : QTc interval... |
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- Erratum
- Perinatal Factors Influencing Clinical Response to Surfactant Replacement Therapy in Neonates with Respiratory Distress Syndrome
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June Dong Park, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
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Clin Exp Pediatr. 1998;41(8):1023-1032. Published online August 15, 1998
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Purpose : Surfactant replacement therapy significantly decreases neonatal complications and mortality in neonates with respiratory distress syndrome(RDS), but clinical responses to the treatment is not consistent. An analysis of the perinatal factors influencing the clinical response to the therapy is important for early detection of high risk and prognosis. The purpose of this study is to analyze the clinical... |
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- Association of Early Postnatal Neutropenia and Development of Bronchopulmonary Dysplasia in Preterm Infants
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Hee Seok Kim, Jun Dong Park, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
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Clin Exp Pediatr. 1998;41(8):1033-1040. Published online August 15, 1998
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Purpose : To see if a similar relationship exists between the decreased number of circulating neutrophils and the development of bronchopulmonary dysplasia(BPD) in preterm infants, we tried to test the hypothesis that claims that preterm infants, who develop BPD, have decreased number of circulating neutrophils than those who do not develop BPD.
Methods : A retrospective cohort study was conducted in... |
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- Original Article
- Hemodynamic Effect of Nitric Oxide Inhalation in the Acute Hypoxic Pulmonary Hypertension Induced Newborn Piglet
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Yun Cil Chang, Won Soon Park, Jung-Hwan Choi, Chong Ku Yun
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Clin Exp Pediatr. 1997;40(10):1394-1409. Published online October 15, 1997
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Purposes : Nitric oxide(NO) is classified as toxic gas in native states, but in most biologic
systems NO acts as a messenger molecule. NO is known as endothelium derived relaxing factor
that modulates tone of vascular smooth muscle. Inhaled NO has been reported to act as a selective
pulmonary vasodilator and we expect that NO inhalation can be used as a successful treatment
modality... |
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- Influence of Phototherapy on Incidence of Patent Ductus Arteriosus in Very Low Birth W eight Infants
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Hee Seok Kim, Ee Kyung Kim, Yun Kyoung Lee, Hee Eun Lee, Chan Hwu Park, Kyung Ran Park, Jun Dong Park, Beyong Il Kim, Woong Heum Kim, Jung-Hwan Choi, Yong Su Yun, Chong Ku Yun, Jeong Mi Lee
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Clin Exp Pediatr. 1997;40(10):1410-1418. Published online October 15, 1997
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Purpose : Patent ductus arteriosus(PDA) is a common disease in very low birth weight
infants(VLBWI). Hemodynamically significant PDA increases the morbidity and mortality of
premature infants. Based on experimental model, light inhibits the constriction of immature piglet' s
ductal rings. No specific mechanism adequately explains the effect of light on the relaxation of
PDA. Several hypotheses, including activation of photosensitive metabolites, alterations in receptors,
or... |
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- Genital Mycoplasmasin the Newborn Infants: Colonization, Prevalence and Clinical Significance
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Yun Sil Chang, Sung Gwon Kim, Beyong Il Kim, Won Soon Park, Bo Hyun Yoon, Eui Chong Kim, Jung-Hwan Choi, Chong Ku Yun
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Clin Exp Pediatr. 1996;39(8):1084-1094. Published online August 15, 1996
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Purpose : The genital mycoplasmas: Ureaplasma urealyticum and Mycoplasma hominis have
recently assumed an increasing importance as neonatal pathogens especially in preterm infants.
The aim of the present study was to determine the prevalence of infections with these organisms
in newborn infants who were admitted in Neonatal Intensive Care Unit(NICU) and who were
suspected having infection in newborn nursery
Methods : Sixty four inborns who... |
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- Incidenceand Risk Factorsof the Retinopathy of Prematurity
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June Dong Park, Jung Hae Kweon, Woong Heum Kim, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun, Sang In Khwarg, Young Suk Yu
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Clin Exp Pediatr. 1996;39(3):326-337. Published online March 15, 1996
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Purpose : Retinopathy of prematurity(ROP) continues to be a serious problem in infants who survived with neonatal intensive care. Nevertheless, there is neither available data about the incidence of ROP which may be the basis of the epidemiology, nor analysis of the risk factors of ROP in Korea. The purpose of this retrospective study was to evaluate the incidence of... |
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- Morphologic Changes of Lung Parenchymal Tissue in Neonatal Rat Pups under Chronic Hyperoxia
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Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
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Clin Exp Pediatr. 1994;37(8):1055-1064. Published online August 15, 1994
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We studied the effects of chronic hyperoxia (>95% oxygen for 14 days) in change of body weight, wet to dry ling weight ratio, and morphologic changes of lung tissue compared with that of room air (21% oxygen for 14 days) in Sprague-Dawley neonatal rat pups.
The results were as follows:
1) In neonatal rat pups exposed to room air (normoxia group), body... |
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- Incidence and Perinatal Risk Factors of Respiratory Distress Syndrome of Newborn
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Yun Sil Chang, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
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Clin Exp Pediatr. 1994;37(8):1065-1077. Published online August 15, 1994
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Over a continuous 4-year period, from January 1989 till December 1992, 7,100 infants were born in Department of Obstetrics and admitted to Nursery or Neonatal Intensive Care Unit of Department of Pediatrics of Seoul National University Children's Hospital. Among them, 126 cases were diagnosed as respiratory distress syndrome (RDS) of newborn.
The total incidence of RDS among all the newborns(inborn)was 1.77%.... |
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- Meta-analysis of Impact of Neonatal Intensive Care on Neurodevelomental Outcome of Very Low Birth Weight Infants
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Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
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Clin Exp Pediatr. 1994;37(7):937-945. Published online July 15, 1994
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We analyzed neurodevelopmental outcome data of 36 selected studies. Data of individual studies were pooled by birth weight group: <800g, <1,000g, <1,500g and by time period of birth year: Period I(pre-intensive care era), 1960-67:Period II(beginning period of intensive care), 1968-76:and Period III(established period of intensive care), 1977-87.
In all weight groups, survival and intact outcome rates based on live birth have... |
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- Periventricular-Intraventricular Hemorrhage in the Full-term Infant
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Hee Sup Kim, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun, In One Kim
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Clin Exp Pediatr. 1994;37(5):642-648. Published online May 15, 1994
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Intraventricular hemorrhage (IVH) is common in the premature infants and occurs mainly in subependymal germinal matrix. In contrast, IVH in the term infants is rare and different in pathogenesis and bleeding sites from those of the premature infants. Most studies of IVH in term infants have been studied by computerized tomography and postmortem examination. Brain ultrasonography which has become a... |
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- Risk Factors and Outcome of Bronchopulmonary Dysplasia
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Beyong Il Kim, Yun Sil Chang, Dong Woo Son, Hae Kyung Han, Jung-Hwan Choi, Chong Ku Yun, In One Kim, Kyung Mo Yeon, Je G. Chi
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Clin Exp Pediatr. 1994;37(1):78-88. Published online January 15, 1994
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The 45 neonates with bronchopulmonary dysplasia among 355 neonates who were managed with mechanical ventilation and oxygen therapy in NICU of Seoul National University Chhildren's Hospital from January 1, 1968 to December 31, 1991, were analyzed for risk factors and outcome.
The results were as follows:
1) The incidence of bronchopulmonary dysplasia was 12.7%
2) Respiratory Distress Syndrome was most common underlying problem.
3)... |
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- Outcome in Infants of Mothers with Systemic Lupus Erythematosus
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Chang Ryul Kim, Young Pyo Chang, Hee Seop Kim, Mi Jung Kim, Byung Il Kim, Jung-Hwan Choi, Chong Ku Yun, Bo Hyun Yoon, Hee Chul Syn, Syng Wook Kim, Seon Yang Park, Hahng Lee
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Clin Exp Pediatr. 1993;36(6):791-804. Published online June 15, 1993
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A large proportion of patients with systemic lupus erythematosus(SLE) are women of reproductive age. Their fetal outcome is undoubtedly less favourable than in haelthy women. Although there is no evidence of an increase in congenital anomalies, increased frequencies of miscarriage, stillbirth, growth retardation, and preterm delivery are recognized It mainly depends on the compromise of uteroplacental circulation such as renal... |
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- Re-evaluation of TSH Screening TEST in Neonates
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Jin Young Song, Dong Woo Son, Beyong Il Kim, Sei Won Yang, Jung-Hwan Choi, Chong Ku Yoon, Hyung Ro Moon
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Clin Exp Pediatr. 1993;36(11):1502-1506. Published online November 15, 1993
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Five years ago, we made the cut-off value of TSH by dry filter paper method as 15μU/ml to screening congenital hypothyrodism. Since then, 1,210 term neonates, who had no perinatal problems, screening test with this cut-off point. Neonates had been recalled for measurement of serum T4/TSH to rule out congenital hypothyroidism if their TSH value by screening tests reveal more... |
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- Case Report
- Transfusion-Acquired Cytomegalovirus Infections in Two Premature Infants
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Dong Wook Kim, Kyung Un No, Mi Jung Kim, Soon Mee Park, Hee Sup Kim, Young Pyo Chang, Hoan Jong Lee, Jung-Hwan Choi, Chong Ku Yun, Je Geun Chi
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Clin Exp Pediatr. 1992;35(8):1141-1147. Published online August 15, 1992
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Transfusion-acquired perinatal cytomegalovirus (CMV) infection can cause significant morbidity and mortality, particularly in premature infants with a birth wight of less than 1,500 gm. This recognizable syndrome consisted of deterioration of respiratory function, hepatosplenogaly, unusual gray pallor with disturbing septic appearance, lymphocytosis, thrombocytopenia and hemolytic anemia.
We experienced transfusion-acquired CMV infections in 2 premature infants with a birth weight of... |
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- Four Cases of Massive Infiltrating Congenital Cystic Hygroma Managed by Bleomycin Sclerosing Therapy
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Hyun Kwack, Dong Wook Kim, Kyung Woon No, Jun Heo, Sun Young Kim, Young Pyo Jang, Jung-Hwan Choi, Chong Ku Yun, Seong En Jung, Gui Won Park, Woo Gi Kim, In Won Kim, Kyung Mo Yeon
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Clin Exp Pediatr. 1992;35(8):1148-1156. Published online August 15, 1992
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Cystic hygroma is a true, benign, congenital multi-cystic tumor. It is thought to be arised from failure of the lymphatic system to communicate with the venous system. Frequently it occurs at birth, and it is found most commonly in the neck as painless and fluctuant mass.
For many years, surgical excision has been considered as the treatment of choice. However, excision... |
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- Original Article
- Cytomegalovirus Infection in Children: The Significance of CMV Specific IgM Antibody Test and Virus Isolation in the Urine
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Dong Wook Kim, Hyun Kwack, Seong Hee Jang, I Seok Kang, Hoan Jong Lee, Jung-Hwan Choi, Jeong Kee Seo, Chong Ku Yun
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Clin Exp Pediatr. 1992;35(7):890-901. Published online July 15, 1992
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The clinical pictures of 44 children with IgM antibody to CMV (cytomegalovirus) by ELISA(enzyme linked immunosorbent assay) were reviewed retrospectively, and the significance of serum CMV specific IgM antibody and virus isolation in the urine was analyzed.
Age of the patients with IgM antibody to CMV ranged from 23 days to 8 years 7 months, and median age was 2 months.... |
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- The Perceptions and Attitudes of Parents and Medical Personnel Toward Fever of Children
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Hyo Nam Cho, Jung-Hwan Choi, Chong Ku Yun
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Clin Exp Pediatr. 1992;35(6):776-787. Published online June 15, 1992
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Children commonly complain of suffering fever ; however, as studies have demonstrated, parents of a febrile infant or young child are inclined to become overly concerned. The pupose of this study was to investigate the perceptions and attitudes of medical personnel as well as parents.
The parents of 189 children and 150 medical personnel (47 nurse-aides, 56 nurses, and 47 doctors)... |
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